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Expanding tRNA recognition of a tRNA synthetase by a single amino acid change

Aspartyl-tRNA synthetase (AspRS) occurs in two types: the discriminating enzyme (D-AspRS) forms only Asp-tRNA(Asp), whereas the nondiscriminating enzyme (ND-AspRS) also synthesizes Asp-tRNA(Asn), which is a required intermediate for protein synthesis in many organisms. We attempted to expand the tRN...

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Hlavní autoři: Feng, Liang, Tumbula-Hansen, Debra, Toogood, Helen, Söll, Dieter
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC156260/
https://ncbi.nlm.nih.gov/pubmed/12730374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0631525100
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