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Catalytic and structural role of the metal ion in dUTP pyrophosphatase

The metal ion dependence of the catalytic activity of recombinant Escherichia coli dUTP pyrophosphatase (dUTPase), an essential enzyme preventing incorporation of uracil into DNA, has been investigated by steady-state kinetic, electron paramagnetic resonance, and electron nuclear double resonance me...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Mustafi, Devkumar, Bekesi, Angela, Vertessy, Beata G., Makinen, Marvin W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156259/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12721364/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1031504100
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