Cytolysis by CCR5-Using Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Is Dependent on Membrane Fusion and Can Be Inhibited by High Levels of CD4 Expression

T-tropic (X4) and dualtropic (R5X4) human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins kill primary and immortalized CD4(+) CXCR4(+) T cells by mechanisms involving membrane fusion. However, because much of HIV-1 infection in vivo is mediated by M-tropic (R5) viruses whose envelope g...

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Pubblicato in:	J Virol
Autori principali:	LaBonte, Jason A., Madani, Navid, Sodroski, Joseph
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156190/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12767984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.12.6645-6659.2003
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