Replicating Parvoviruses That Target Colon Cancer Cells
The wnt signaling pathway is constitutively activated in colon tumors by mutations in the adenomatous polyposis coli and β-catenin genes. We have modified the minute virus of mice (MVM) P4 promoter to make it responsive to wnt signaling by inserting binding sites for the heterodimeric β-catenin/Tcf...
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| Veröffentlicht in: | J Virol |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156172/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12767988/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.12.6683-6691.2003 |
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