Determinants of Increased Replicative Capacity of Serially Passaged Simian Immunodeficiency Virus with nef Deleted in Rhesus Monkeys

Most rhesus macaques infected with simian immunodeficiency virus SIVmac239 with nef deleted (either Δnef or ΔnefΔvprΔUS [Δ3]) control viral replication and do not progress to AIDS. Some monkeys, however, develop moderate viral load set points and progress to AIDS. When simian immunodeficiency viruse...

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Bibliographic Details
Main Authors: Alexander, Louis, Illyinskii, Petr O., Lang, Sabine M., Means, Robert E., Lifson, Jeffrey, Mansfield, Keith, Desrosiers, Ronald C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC156171/
https://ncbi.nlm.nih.gov/pubmed/12768002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.12.6823-6835.2003
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