Mutagenic effects of 2-hydroxy-dATP on replication in a HeLa extract: induction of substitution and deletion mutations

The mutagenicity of an oxidized form of dATP, 2-hydroxydeoxyadenosine 5′-triphosphate (2-OH-dATP), was examined using an SV40 origin-dependent in vitro replication system with a HeLa extract. 2-OH-dATP induced mutations in a dose-dependent manner and elicited substitution and deletion mutations. Of...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Satou, Kazuya, Harashima, Hideyoshi, Kamiya, Hiroyuki
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2003
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC156049/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12736306/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg368
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