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A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb

We address the molecular control of myogenesis in progenitor cells derived from the hypaxial somite. Null mutations in Pax3, a key regulator of skeletal muscle formation, lead to cell death in this domain. We have developed a novel allele of Pax3 encoding a Pax3–engrailed fusion protein that acts as...

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Detalles Bibliográficos
Autores principales: Bajard, Lola, Relaix, Frédéric, Lagha, Mounia, Rocancourt, Didier, Daubas, Philippe, Buckingham, Margaret E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1560418/
https://ncbi.nlm.nih.gov/pubmed/16951257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.382806
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