The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB

RNA polymerase (pol) III transcription increases within minutes of serum addition to growth-arrested fibroblasts. We show that ERK mitogen-activated protein kinases regulate pol III output by directly binding and phosphorylating the BRF1 subunit of transcription factor TFIIIB. Blocking the ERK signa...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Felton-Edkins, Zoe A., Fairley, Jennifer A., Graham, Emma L., Johnston, Imogen M., White, Robert J., Scott, Pamela H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155998/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12743036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg240
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