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The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB

RNA polymerase (pol) III transcription increases within minutes of serum addition to growth-arrested fibroblasts. We show that ERK mitogen-activated protein kinases regulate pol III output by directly binding and phosphorylating the BRF1 subunit of transcription factor TFIIIB. Blocking the ERK signa...

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Detalhes bibliográficos
Main Authors: Felton-Edkins, Zoe A., Fairley, Jennifer A., Graham, Emma L., Johnston, Imogen M., White, Robert J., Scott, Pamela H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155998/
https://ncbi.nlm.nih.gov/pubmed/12743036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg240
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