RAD18-independent ubiquitination of proliferating-cell nuclear antigen in the avian cell line DT40

Ubiquitination of proliferating-cell nuclear antigen (PCNA) at K164 by RAD6/RAD18 has a key role in DNA damage tolerance in yeast. Here, we report on the first genetic study of this modification in a vertebrate cell. As in yeast, mutation of K164 of PCNA to arginine in the avian cell line DT40 resul...

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Bibliographic Details
Main Authors: Simpson, Laura J, Ross, Anna-Laura, Szüts, Dávid, Alviani, Cherry A, Oestergaard, Vibe H, Patel, Ketan J, Sale, Julian E
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Scientific Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559672/
https://ncbi.nlm.nih.gov/pubmed/16888649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400777
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