Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau

BACKGROUND: Aberrant hyperphosphorylation of tau protein has been implicated in a variety of neurodegenerative disorders. Although a number of protein kinases have been shown to phosphorylate tau in vitro and in vivo, the molecular mechanisms by which tau phosphorylation is regulated pathophysiologi...

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Detalhes bibliográficos
Main Authors: Zhang, Xue, Zhang, Yun-wu, Liu, Shijie, Bulloj, Ayelen, Tong, Gary G, Zhang, Zhuohua, Liao, Francesca-Fang, Xu, Huaxi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559623/
https://ncbi.nlm.nih.gov/pubmed/16930454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-1-7
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