Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes

Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding...

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Autors principals: Reche, Pedro A, Keskin, Derin B, Hussey, Rebecca E, Ancuta, Petronela, Gabuzda, Dana, Reinherz, Ellis L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559620/
https://ncbi.nlm.nih.gov/pubmed/16674822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9433-5-1
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