Prodrugs of Cephalosporin RWJ-333441 (MC-04,546) with Improved Aqueous Solubility

To improve the aqueous solubility of anti-methicillin-resistant Staphylococcus aureus cephalosporin RWJ-333441 for parenteral administration, acyl derivatives of the C-3 primary amino group were prepared and evaluated for solubility, cleavage in serum in vitro, and conversion to RWJ-333441 in vivo....

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Main Authors: Hecker, Scott J., Calkins, Trevor, Price, Mary E., Huie, Keith, Chen, Sharon, Glinka, Tomasz W., Dudley, Michael N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC155843/
https://ncbi.nlm.nih.gov/pubmed/12760896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.6.2043-2046.2003
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