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Prodrugs of Cephalosporin RWJ-333441 (MC-04,546) with Improved Aqueous Solubility
To improve the aqueous solubility of anti-methicillin-resistant Staphylococcus aureus cephalosporin RWJ-333441 for parenteral administration, acyl derivatives of the C-3 primary amino group were prepared and evaluated for solubility, cleavage in serum in vitro, and conversion to RWJ-333441 in vivo....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC155843/ https://ncbi.nlm.nih.gov/pubmed/12760896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.6.2043-2046.2003 |
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