Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the β-subunit of the amiloride-sensitive epithelial sodium channel

The amiloride-sensitive epithelial sodium channel (ENaC) is a heteromultimer of three homologous subunits (α-, β-, and γ-subunits). To study the role of the β-subunit in vivo, we analyzed mice in which the βENaC gene locus was disrupted. These mice showed low levels of βENaC mRNA expression in kidne...

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Hauptverfasser: Pradervand, Sylvain, Barker, Pierre M., Wang, Qing, Ernst, Stephen A., Beermann, Friedrich, Grubb, Barbara R., Burnier, Michel, Schmidt, Andrea, Bindels, Rene J. M., Gatzy, John T., Rossier, Bernard C., Hummler, Edith
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1999
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15577/
https://ncbi.nlm.nih.gov/pubmed/9990093
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