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Pokeweed antiviral protein depurinates the sarcin/ricin loop of the rRNA prior to binding of aminoacyl-tRNA to the ribosomal A-site

Ribosome-inactivating proteins, such as the pokeweed antiviral protein (PAP), inhibit translation by depurinating the conserved sarcin/ricin loop of the large ribosomal RNA. Depurinated ribosomes are unable to bind elongation factor 2, and, thus, the translocation step of the elongation cycle is inh...

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Detaylı Bibliyografya
Asıl Yazarlar: Mansouri, Sheila, Nourollahzadeh, Emad, Hudak, Katalin A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557698/
https://ncbi.nlm.nih.gov/pubmed/16888324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.70306
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