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A novel mechanism for inhibition of translation by pokeweed antiviral protein: depurination of the capped RNA template.

Pokeweed antiviral protein (PAP) is known to inactivate ribosomes by removal of a specific adenine from the sarcin/ricin (S/R) loop of the large rRNA, thereby inhibiting translation. We demonstrate here that in addition to the previously identified adenine (A4324), PAP removes another adenine (A4321...

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Autori principali: Hudak, K A, Wang, P, Tumer, N E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369919/
https://ncbi.nlm.nih.gov/pubmed/10744021
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