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Coupling of Global and Local Vibrational Modes in Dynamic Allostery of Proteins

It is now recognized that internal global protein dynamics play an important role in the allosteric function of many proteins. Alterations of protein flexibility on effector binding affect the entropic cost of binding at a distant site. We present a coarse-grained model for a potential amplification...

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Détails bibliographiques
Auteurs principaux: Hawkins, Rhoda J., McLeish, Tom C. B.
Format: Artigo
Langue:Inglês
Publié: Biophysical Society 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1557547/
https://ncbi.nlm.nih.gov/pubmed/16798805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.082180
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