Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-alpha 1-antitrypsin complexation to disease activity in Wegener's granulomatosis.

In the sera of patients with Wegener's granulomatosis (WG), C-ANCA can be detected that are directed against proteinase 3 (PR3). We have previously observed that C-ANCA interfere with PR3 proteolytic activity and with complexation of PR3 with its major physiologic inhibitor, alpha 1-antitrypsin...

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Bibliographic Details
Main Authors: Dolman, K M, Stegeman, C A, van de Wiel, B A, Hack, C E, von dem Borne, A E, Kallenberg, C G, Goldschmeding, R
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1554914/
https://ncbi.nlm.nih.gov/pubmed/8370167
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