IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM-rheumatoid factor production in patients with rheumatoid arthritis.

There is evidence to suggest that CD5+ B cells may be associated with autoimmunity, e.g. they are increased in patients with rheumatoid arthritis (RA). In this study, we found that the expression of CD5 on RA B cells increased spontaneously, following culture for up to 4 days in vitro in the absence...

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Detalhes bibliográficos
Main Authors: Hidaka, T, Kitani, A, Hara, M, Harigai, M, Suzuki, K, Kawaguchi, Y, Ishizuka, T, Kawagoe, M, Nakamura, H
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1554450/
https://ncbi.nlm.nih.gov/pubmed/1379131
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