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Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

Recent experiments have established that Sox9 is required for chondrocyte differentiation. Here, we show that fibroblast growth factors (FGFs) markedly enhance Sox9 expression in mouse primary chondrocytes as well as in C3H10T1/2 cells that express low levels of Sox9. FGFs also strongly increase the...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Murakami, Shunichi, Kan, Mikio, McKeehan, Wallace L., de Crombrugghe, Benoit
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15539/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10655493/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.3.1113
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