Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine

Compared with a single-stage antigen-based vaccine, a multistage and multivalent Plasmodium falciparum vaccine would be more efficacious by inducing “multiple layers” of immunity. We have constructed a synthetic gene that encodes for 12 B cell, 6 T cell proliferative, and 3 cytotoxic T lymphocyte ep...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shi, Ya Ping, Hasnain, Seyed E., Sacci, John B., Holloway, Brian P., Fujioka, Hisashi, Kumar, Nirbhay, Wohlhueter, Robert, Hoffman, Stephen L., Collins, William E., Lal, Altaf A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1615
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