Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine

Compared with a single-stage antigen-based vaccine, a multistage and multivalent Plasmodium falciparum vaccine would be more efficacious by inducing “multiple layers” of immunity. We have constructed a synthetic gene that encodes for 12 B cell, 6 T cell proliferative, and 3 cytotoxic T lymphocyte ep...

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Detalhes bibliográficos
Main Authors: Shi, Ya Ping, Hasnain, Seyed E., Sacci, John B., Holloway, Brian P., Fujioka, Hisashi, Kumar, Nirbhay, Wohlhueter, Robert, Hoffman, Stephen L., Collins, William E., Lal, Altaf A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15536/
https://ncbi.nlm.nih.gov/pubmed/9990073
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