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Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

Human mastocytosis is characterized by increased mast cells. It usually occurs as a sporadic disease that is often transient and limited in children and persistent or progressive in adults. The c-KIT protooncogene encodes KIT, a tyrosine kinase that is the receptor for mast cell growth factor. Becau...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Longley, B. Jack, Metcalfe, Dean D., Tharp, Michael, Wang, Xiaomei, Tyrrell, Lynda, Lu, Shu-zhuang, Heitjan, David, Ma, Yongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15534/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990072/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1609
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