3,4-DEHYDRODEBRISOQUINE, A NOVEL DEBRISOQUINE METABOLITE FORMED FROM 4-HYDROXYDEBRISOQUINE THAT IMPACTS THE CYP2D6 METABOLIC RATIO

Considerable unexplained inter-subject variability in the debrisoquine metabolic ratio (urinary debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. We speculated that debrisoquine was converted to as yet undisclosed metabolites. Thirteen healthy young volunteers, nine CYP2...

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Detalhes bibliográficos
Main Authors: Zhen, Yueying, Slanař, Ondřej, Krausz, Kristopher W., Chen, Chi, Slavík, Josef, McPhail, Kerry L., Zabriskie, T. Mark, Perlík, František, Gonzalez, Frank J., Idle, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1553181/
https://ncbi.nlm.nih.gov/pubmed/16782768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.105.008920
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