Activin Induces x-Zone Apoptosis That Inhibits Luteinizing Hormone-Dependent Adrenocortical Tumor Formation in Inhibin-Deficient Mice

Inhibin and activin are members of the transforming growth factor β (TGF-β) family of ligands produced and secreted primarily by the gonads and adrenals. Inhibin-null (INH(−/−)) mice develop gonadal tumors and—when gonadectomized—adrenocortical carcinoma. The mechanisms leading to adrenal tumorigene...

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Detalhes bibliográficos
Main Authors: Beuschlein, Felix, Looyenga, Brendan D., Bleasdale, Stephanie E., Mutch, Chris, Bavers, David L., Parlow, Albert F., Nilson, John H., Hammer, Gary D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155220/
https://ncbi.nlm.nih.gov/pubmed/12748296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.11.3951-3964.2003
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