Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca(2+) release, and catecholaminergic polymorphic ventricular tachycardia

Cardiac calsequestrin (Casq2) is thought to be the key sarcoplasmic reticulum (SR) Ca(2+) storage protein essential for SR Ca(2+) release in mammalian heart. Human CASQ2 mutations are associated with catecholaminergic ventricular tachycardia. However, homozygous mutation carriers presumably lacking...

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Detalhes bibliográficos
Main Authors: Knollmann, Björn C., Chopra, Nagesh, Hlaing, Thinn, Akin, Brandy, Yang, Tao, Ettensohn, Kristen, Knollmann, Barbara E.C., Horton, Kenneth D., Weissman, Neil J., Holinstat, Izabela, Zhang, Wei, Roden, Dan M., Jones, Larry R., Franzini-Armstrong, Clara, Pfeifer, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1551934/
https://ncbi.nlm.nih.gov/pubmed/16932808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI29128
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