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Urinary Metabolite Profiling Reveals CYP1A2-mediated Metabolism of Aminoflavone (NSC 686288)

Aminoflavone (AF, NSC 686288), a candidate chemotherapeutic agent, possesses a unique antiproliferative profile against tumor cells. Metabolic bioactivation of AF by drug metabolizing enzymes, especially CYP1A monooxygenases, has been implicated as an underlying mechanism for its selective cytotoxic...

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Sonraí Bibleagrafaíochta
Main Authors: Chen, Chi, Meng, Linghua, Ma, Xiaochao, Krausz, Kristopher W., Pommier, Yves, Idle, Jeffrey R., Gonzalez, Frank J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1551906/
https://ncbi.nlm.nih.gov/pubmed/16775196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.106.105213
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