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Urinary Metabolite Profiling Reveals CYP1A2-mediated Metabolism of Aminoflavone (NSC 686288)
Aminoflavone (AF, NSC 686288), a candidate chemotherapeutic agent, possesses a unique antiproliferative profile against tumor cells. Metabolic bioactivation of AF by drug metabolizing enzymes, especially CYP1A monooxygenases, has been implicated as an underlying mechanism for its selective cytotoxic...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1551906/ https://ncbi.nlm.nih.gov/pubmed/16775196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.106.105213 |
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