Exploiting the Natural Diversity in Adenovirus Tropism for Therapy and Prevention of Disease

Since targeting of recombinant adenovirus vectors to defined cell types in vivo is a major challenge in gene therapy and vaccinology, we explored the natural diversity in human adenovirus tissue tropism. Hereto, we constructed a library of Ad5 vectors carrying fibers from other human serotypes. From...

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Hlavní autoři: Havenga, M. J. E., Lemckert, A. A. C., Ophorst, O. J. A. E., van Meijer, M., Germeraad, W. T. V., Grimbergen, J., van den Doel, M. A., Vogels, R., van Deutekom, J., Janson, A. A. M., de Bruijn, J. D., Uytdehaag, F., Quax, P. H. A., Logtenberg, T., Mehtali, M., Bout, A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Gene Therapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC155076/
https://ncbi.nlm.nih.gov/pubmed/11932426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.9.4612-4620.2002
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