A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes

Appropriate subcellular localization is crucial for regulation of NF-κB function. Herein, we show that latent NF-κB complexes can enter and exit the nucleus in preinduction states. The nuclear export inhibitor leptomycin B (LMB) sequestered NF-κB/IκBα complexes in the nucleus. Using deletion and sit...

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Publikašuvnnas:	Proc Natl Acad Sci U S A
Váldodahkkit:	Huang, Tony T., Kudo, Nobuaki, Yoshida, Minoru, Miyamoto, Shigeki
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	National Academy of Sciences 2000
Fáttát:	Biological Sciences
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15505/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10655476/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.3.1014
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