Rational discovery of novel nuclear hormone receptor antagonists
Nuclear hormone receptors (NRs) are potential targets for therapeutic approaches to many clinical conditions, including cancer, diabetes, and neurological diseases. The crystal structure of the ligand binding domain of agonist-bound NRs enables the design of compounds with agonist activity. However,...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15503/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10655475/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.3.1008 |
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