Indomethacin-Induced Apoptosis in Esophageal Adenocarcinoma Cells Involves Upregulation of Bax and Translocation of Mitochondrial Cytochrome C Independent of COX-2 Expression

The prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to exert a chemopreventive effect in esophageal and other gastrointestinal tumors. The precise mechanism by which this occurs, however, is unknown. While the inhibition of COX-2 as a potential explanation for this chem...

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Main Authors: Aggarwal, Sanjeev, Taneja, Neelam, Lin, Lin, Orringer, Mark B, Rehemtulla, Alnawaz, Beer, David G
Format: Artigo
Jezik:Inglês
Izdano: Nature America, Inc. 2000
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550298/
https://ncbi.nlm.nih.gov/pubmed/11005569
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