PTEN inhibits IL-2 receptor–mediated expansion of CD4(+) CD25(+) Tregs

One of the greatest barriers against harnessing the potential of CD4(+)CD25(+) Tregs as a cellular immunotherapy is their hypoproliferative phenotype. We have previously shown that the hypoproliferative response of Tregs to IL-2 is associated with defective downstream PI3K signaling. Here, we demons...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Walsh, Patrick T., Buckler, Jodi L., Zhang, Jidong, Gelman, Andrew E., Dalton, Nicole M., Taylor, Devon K., Bensinger, Steven J., Hancock, Wayne W., Turka, Laurence A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2006
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550279/
https://ncbi.nlm.nih.gov/pubmed/16917540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28057
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg