Extensive Cross-Reactivity of CD4(+) Adenovirus-Specific T Cells: Implications for Immunotherapy and Gene Therapy

Adenovirus (Ad)-specific T-cell responses in healthy adult donors were investigated. Ad5, inactivated by methylene blue plus visible light, induced proliferation and gamma interferon (IFN-γ) production in peripheral blood mononuclear cells of the majority of donors. Responding T cells were CD4(+) an...

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Bibliographic Details
Main Authors: Heemskerk, Bianca, Veltrop-Duits, Louise A., van Vreeswijk, Tamara, ten Dam, Monique M., Heidt, Sebastiaan, Toes, Rene E. M., van Tol, Maarten J. D., Schilham, Marco W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC155022/
https://ncbi.nlm.nih.gov/pubmed/12743315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.11.6562-6566.2003
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