Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Phosphonoformate (foscarnet) is a pyrophosphate (PP(i)) analogue and a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), acting through the PP(i) binding site on the enzyme. HIV-1 RT can unblock a chain-terminated DNA primer by phosphorolytic transfer of the...

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Detalhes bibliográficos
Main Authors: Meyer, Peter R., Matsuura, Suzanne E., Zonarich, Dianna, Chopra, Rahul R., Pendarvis, Eric, Bazmi, Holly Z., Mellors, John W., Scott, Walter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC155000/
https://ncbi.nlm.nih.gov/pubmed/12743270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.11.6127-6137.2003
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