Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Phosphonoformate (foscarnet) is a pyrophosphate (PP(i)) analogue and a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), acting through the PP(i) binding site on the enzyme. HIV-1 RT can unblock a chain-terminated DNA primer by phosphorolytic transfer of the...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Meyer, Peter R., Matsuura, Suzanne E., Zonarich, Dianna, Chopra, Rahul R., Pendarvis, Eric, Bazmi, Holly Z., Mellors, John W., Scott, Walter A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Vaccines and Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC155000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12743270/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.11.6127-6137.2003
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