Reconstruction of Mycobacterial Dehalogenase Rv2579 by Cumulative Mutagenesis of Haloalkane Dehalogenase LinB

The homology model of protein Rv2579 from Mycobacterium tuberculosis H37Rv was compared with the crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26, and this analysis revealed that 6 of 19 amino acid residues which form an active site and entrance tunnel are differ...

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Bibliographic Details
Main Authors: Nagata, Yuji, Prokop, Zbyněk, Marvanová, Soňa, Sýkorová, Jana, Monincová, Marta, Tsuda, Masataka, Damborský, Jiří
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Enzymology and Protein Engineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC154798/
https://ncbi.nlm.nih.gov/pubmed/12676719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.4.2349-2355.2003
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