Reconstruction of Mycobacterial Dehalogenase Rv2579 by Cumulative Mutagenesis of Haloalkane Dehalogenase LinB

The homology model of protein Rv2579 from Mycobacterium tuberculosis H37Rv was compared with the crystal structure of haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT26, and this analysis revealed that 6 of 19 amino acid residues which form an active site and entrance tunnel are differ...

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Detalhes bibliográficos

Publicado no:	Appl Environ Microbiol
Principais autores:	Nagata, Yuji, Prokop, Zbyněk, Marvanová, Soňa, Sýkorová, Jana, Monincová, Marta, Tsuda, Masataka, Damborský, Jiří
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Enzymology and Protein Engineering
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12676719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.69.4.2349-2355.2003
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