A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB

Many enzymes have buried active sites. The properties of the tunnels connecting the active site with bulk solvent affect ligand binding and unbinding and also the catalytic properties. Here, we investigate ligand passage in the haloalkane dehalogenase enzyme LinB and the effect of replacing leucine...

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Detalhes bibliográficos
Main Authors: Biedermannová, Lada, Prokop, Zbyněk, Gora, Artur, Chovancová, Eva, Kovács, Mihály, Damborský, Jiří, Wade, Rebecca C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436548/
https://ncbi.nlm.nih.gov/pubmed/22745119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377853
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