G(1) cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation

The tumor suppressor Smad4/Dpc4 is a transcription activator that binds specific DNA sequences and whose nuclear localization is induced after exposure to type β transforming growth factor-like cytokines. We explored an inducible system in which Smad4 protein is activated by translocation to the nuc...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Dai, Jia Le, Bansal, Ravi K., Kern, Scott E.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15479/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9990040/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.4.1427
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