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Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

Antibody-based anticancer agents are promising chemotherapeutic agents. Among these agents, Herceptin (trastuzumab), a humanized anti-human epidermal growth factor receptor 2 (HER2/c-erbB2) monoclonal antibody, has been used successfully in patients with breast cancer. However, in patients with brai...

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Detalhes bibliográficos
Main Authors: Kinoshita, Manabu, McDannold, Nathan, Jolesz, Ferenc A., Hynynen, Kullervo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544236/
https://ncbi.nlm.nih.gov/pubmed/16868082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604318103
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