DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype

Recently, we have identified proinsulin (P-Ins)(73-90) as an immunodominant T cell epitope of HLA-DRB1*0401 (DR4) subjects with β-islet cell autoimmunity and of HLA-DR4/CD4 double-transgenic mice immunized with human P-Ins. We have compared the fine specificities of one human CD4 T cell clone and tw...

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Bibliografiset tiedot
Päätekijät: Durinovic-Belló, Ivana, Rosinger, Silke, Olson, Jennifer A., Congia, Mauro, Ahmad, Regina C., Rickert, Mathias, Hampl, Johannes, Kalbacher, Hubert, Drijfhout, Jan W., Mellins, Elizabeth D., Al Dahouk, Sascha, Kamradt, Thomas, Maeurer, Markus J., Nhan, Carol, Roep, Bart O., Boehm, Bernhard O., Polychronakos, Constantin, Nepom, Gerald T., Karges, Wolfram, McDevitt, Hugh O., Sønderstrup, Grete
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2006
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544230/
https://ncbi.nlm.nih.gov/pubmed/16868084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603682103
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