Genes and pathways downstream of telomerase in melanoma metastasis

Recent studies have demonstrated a role for telomerase in driving tumor progression, but its mechanism of action remains unclear. Here we show that stable, ribozyme-mediated suppression of mouse telomerase RNA reduced telomerase RNA expression, telomerase activity, and telomere length, which signifi...

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Detalhes bibliográficos
Main Authors: Bagheri, Sepideh, Nosrati, Mehdi, Li, Shang, Fong, Sylvia, Torabian, Sima, Rangel, Javier, Moore, Dan H., Federman, Scot, LaPosa, Rebecca R., Baehner, Frederick L., Sagebiel, Richard W., Cleaver, James E., Haqq, Christopher, Debs, Robert J., Blackburn, Elizabeth H., Kashani-Sabet, Mohammed
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544082/
https://ncbi.nlm.nih.gov/pubmed/16847266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510085103
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