Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation

The search for small-molecule drugs that act at peptide hormone receptors has resulted in the identification of a wide variety of antagonists. In contrast, the discovery of nonpeptide agonists has been far more elusive. We have used a constitutively active mutant of the cholecystokinin 2 receptor (C...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Kopin, Alan S., McBride, Edward W., Chen, Ci, Freidinger, Roger M., Chen, Duan, Zhao, Chun-Mei, Beinborn, Martin
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2003
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154378/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12697901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0831223100
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