Cancer-related changes in prostate DNA as men age and early identification of metastasis in primary prostate tumors

Using statistical analyses of Fourier transform-IR spectra, we show that DNA of the histologically normal prostates of men 16–80 years old undergoes structural changes in the bases and backbone with increasing age. Of the older men (ages 55–80), 42% exhibited a DNA phenotype mimicking that of primar...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Malins, Donald C., Johnson, Paul M., Barker, Edward A., Polissar, Nayak L., Wheeler, Thomas M., Anderson, Katie M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12702759/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0931396100
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