Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

Polycystic kidney disease (PKD) is the most common genetic cause of renal failure in humans. Several proteins that are encoded by genes associated with PKD have recently been identified in primary cilia in renal tubular epithelia. These findings have suggested that abnormalities in cilia formation a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lin, Fangming, Hiesberger, Thomas, Cordes, Kimberly, Sinclair, Angus M., Goldstein, Lawrence S. B., Somlo, Stefan, Igarashi, Peter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12672950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0836980100
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