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Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

Polycystic kidney disease (PKD) is the most common genetic cause of renal failure in humans. Several proteins that are encoded by genes associated with PKD have recently been identified in primary cilia in renal tubular epithelia. These findings have suggested that abnormalities in cilia formation a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lin, Fangming, Hiesberger, Thomas, Cordes, Kimberly, Sinclair, Angus M., Goldstein, Lawrence S. B., Somlo, Stefan, Igarashi, Peter
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154337/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12672950/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0836980100
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