The molecular basis for the chemical denaturation of proteins by urea
Molecular dynamics simulations of the protein chymotrypsin inhibitor 2 in 8 M urea at 60°C were undertaken to investigate the molecular basis of chemical denaturation. The protein unfolded rapidly under these conditions, but it retained its native structure in a control simulation in water at the sa...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC154312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12702764/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0930122100 |
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