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Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug–topoisomerase complexes
The cytotoxicity of several important antitumor drugs depends on formation of the covalent topoisomerase–DNA cleavage complex. However, cellular processes such as DNA replication are necessary to convert the cleavage complex into a cytotoxic lesion, but the molecular mechanism of this conversion and...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC154295/ https://ncbi.nlm.nih.gov/pubmed/12704241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0835166100 |
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