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Production of heavy-chain class-switch variants of human monoclonal antibody by recombinant DNA technology.

We have previously established a human-mouse heterohybridoma (H6-3C4), which produced a human sperm-immobilizing antibody (mu, lambda of human type). The human rearranged immunoglobulin mu-chain and lambda-chain genes were cloned from the hybridoma H6-3C4. The cloned V region of the heavy chain (VH)...

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Autors principals: Komori, S, Yamasaki, N, Shigeta, M, Isojima, S, Watanabe, T
Format: Artigo
Idioma:Inglês
Publicat: 1988
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1541674/
https://ncbi.nlm.nih.gov/pubmed/3133144
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