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A monoclonal DNA-binding autoantibody causes a deterioration in renal function in MRL mice with lupus disease.

Two DNA-binding monoclonal antibodies (MoAb) derived from lupus mice were examined for their effects on kidney function. Antibody IV-228, reactive with single-stranded DNA (ssDNA) but not double-stranded DNA (dsDNA) significantly altered kidney function in some MRL/Mp-lpr/lpr (MRL/lpr) mice with lup...

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Bibliografiske detaljer
Main Authors: Lake, R A, Staines, N A
Format: Artigo
Sprog:Inglês
Udgivet: 1988
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1541458/
https://ncbi.nlm.nih.gov/pubmed/3048810
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